BIOLOGY@WORK JE SNYDER PROJECTS CV




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Jessica E. Snyder, PhD


Objective

Engineer and explorer seeking an ambitious team to build, as much as evolve, biological industrial design.


Work Experience


Blue Marble Space Institute of Science
Affiliate Research Scientist     2023 - Present
Co-Investigator to engineer an astropharamcy that produces peptide pharmaceuticals. This proposal team has completed a proof of concept for the Astropharmacy, an on-demand drug production platform for aerospace medicine. This project is funded by the NASA Innnovative Advanced Concepts (NIAC) program.

Odyssey SpaceWorks
Cofounder/Head of Science     2022-2023
Build and operate an automated R&D facility in low Earth orbit for life sciences - made one small satellite at a time. Our lab modules apply supervised biological work and permissioned evolution during spaceflight. First mission to launch October 2023.

RoosterBio
Bioprocessing Application Scientist    2021-2022
Accelerate human mesenchymal stromal cell product and process development. Collaborate with academics and industry to leverage a well-dened cellular therapy product line for scalable regenerative medicine cures.

Universities Space Research Association, contracted to NASA Ames Research Center
Scientist + Synthetic Biology Task Lead     2017-2020
Biological industrial design to outt human missions to space. Built biotechnology alongside evolutionary and synthetic biologists to reverse engineer life from extreme environments. Projects included: Digitizing a sea sponge to 3D-print a living lter; a portable device to make protein-based drugs; and eld work in Antarctica.

Massachusetts Institute of Technology, Senseable City Lab
Postdoctoral Fellow     2015-2017
A partially anonymized public health census using biology, data, and civic infrastructure. As part of the Underworlds team, I automated wastewater sampling to measure the bacteria, virus, and chemicals in dierent neighborhoods. Our geolocated dataset became a heatmap of human health and consumption. Instances of the technology were deployed in Boston and Kuwait. The project has become the company BioBot Analytics.

Drexel University, Mechanical Engineering Department, Biofabrication Lab
Research Fellow / PhD Candidate     2009-2014
Developed manufacturing processes to build a model of human liver for space ight medicine. Used scaold-guided tissue engineering to reproduce the anatomical, multi-cell type structure of hepatic tissue. In collaboration with NASA Johnson Space Center, we used the 3D-printed model to measure drug toxicity in space-like environments. To build as much as grow biotechnology for human missions to space.

Department of Defense, Defense Intelligence Agency
Analyst     2008


Inventions

  1. Heterogeneous laments, methods of producing the same, scaolds, methods of producing the same, droplets, ... Sun, Wei, Qudus Hamid, and Jessica Snyder. WO/2017/019300 (2017)
    https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2017019300
  2. Compositions and Methods for Functionalized Patterning of Tissue Engineering Substrates Including Bioprinting Cell-Laden Constructs for Multicompartment Tissue Chambers. Sun, Wei, Jessica Snyder, Robert Chang, Eda Yildirim, Alexander Fridman, and Halim Ayan. U.S. Patent 12 872,992 (2011)
    https://www.freepatentsonline.com/y2011/0136162.html


Service


Montefiore Health System, The Virtual Reality Fine Art Program
Collaborator    2016-present

Joined a clinical trial of virtual reality as a non-pharmacological pain management strategy. We collect physiological feedback using wearables to tailor-make immersive entertainment experiences that hold promise for guiding pediatric patients towards calmer emotional states, potentially reducing opiate prescriptions to pediatric pateints during rehabilitation.


Funded Grants - Current Support

  1. Mycotecture Off Planet. NASA Innovative Advanced Concepts (NIAC) Phase II 2021. Lynn J. Rothschild, Christopher Maurer, Debbie Senesky, Ivan Gláucio Paulino Lima, Jim Head, Jessica Snyder, Maikel Rheinstadter, Martyn Dade-Robertson. $250k / 2 years
    Funding Announcement: https://www.nasa.gov/directorates/spacetech/niac/2021_Phase_I/Mycotecture_Off_Planet/
    Progress: https://ntrs.nasa.gov/citations/20210026908
  2. An Astropharmacy. NASA Innovative Advanced Concepts (NIAC) Phase I 2020. Lynn J. Rothschild (PI), Kate Adamala, David Loftus, Mike Jewett, Jessica Snyder, Ivan Gláucio Paulino Lima, Hans-Joachim Wieden. $125k / 9 months - extended due to pandemic-related closures
    Funding Announcement: https://www.nasa.gov/directorates/spacetech/niac/2020_Phase_I_Phase_II/Astropharmacy/

Scopus Metrics Overview

h-index            10
Citations           438
Authored Documents     25


Publications

  1. Averesch NJ, Berliner AJ, Nangle SN, Zezulka S, Vengerova GL, Ho D, Casale CA, Lehner BA, Snyder JE, Clark KB, Dartnell LR. Microbial biomanufacturing for space-exploration—what to take and when to make. Nature Communications. 2023 Apr 21;14(1):2311.
    https://www.nature.com/articles/s41467-023-37910-1
  2. Averesch, N.J., Berliner, A.J., Nangle, S.N., Zezulka, S., Vengerova, G.L., Ho, D., Casale, C.A., Lehner, B.A., Snyder, J.E.J., Clark, K.B. and Dartnell, L.R., 2022. Biomanufacturing for Space-Exploration - What to Take and When to Make.
    https://www.preprints.org/manuscript/202207.0329/v1
  3. Zajkowski T, Lee MD, Mondal SS, Carbajal A, Dec R, Brennock PD, Piast RW, Snyder JE, Bense NB, Dzwolak W, Jarosz DF. The hunt for ancient prions: archaeal prion-like domains form amyloid-based epigenetic elements. Molecular Biology and Evolution. 2021 May;38(5):2088-103.
    https://doi.org/10.1093/molbev/msab010
  4. Lehner BA, Schlechten J, Filosa A, Pou AC, Mazzotta DG, Spina F, Teeney L, Snyder JE, Tjon SY, Meyer AS, Brouns SJ. End-to-end mission design for microbial ISRU activities as preparation for a moon village. Acta Astronautica. 2019 Sep 1;162:216-26.
    https://doi.org/10.1016/j.actaastro.2019.06.001
  5. Snyder JE, Walsh D, Carr PA, Rothschild LJ. A makerspace for life support systems in space. Trends in biotechnology. 2019 Nov 1;37(11):1164-74.
    https://doi.org/10.1016/j.tibtech.2019.05.003
  6. Liu Y, Hamid Q, Snyder JE, Wang C, Sun W. Evaluating fabrication feasibility and biomedical application potential of in situ 3D printing technology. Rapid Prototyping Journal. 2016 Oct 17.
    https://doi.org/10.1108/RPJ-07-2015-0090
  7. Snyder JE, Hamid Q, Sun W. Fabrication of microuidic manifold by precision extrusion deposition and replica molding for cell-laden device. Journal of Manufacturing Science and Engineering. 2016 Apr 1;138(4).
    https://doi.org/10.1115/1.4031551
  8. Snyder JE, Son AR, Hamid Q, Wu H, Sun W. Hetero-cellular prototyping by synchronized multi-material bioprinting for rotary cell culture system. Biofabrication. 2015 Dec 29;8(1):015002.
    https://doi.org/10.1088/1758-5090/8/1/015002
  9. Snyder JE, Son AR, Hamid Q, Wang C, Lui Y, Sun W. Mesenchymal stem cell printing and process regulated cell properties. Biofabrication. 2015 Dec 22;7(4):044106.
    https://doi.org/10.1088/1758-5090/7/4/044106
  10. Wang C, Hamid Q, Snyder JE, Ayan H, Sun W. Localized surface functionalization of polycaprolactone with atmospheric-pressure microplasma jet. Biomedical Physics & Engineering Express. 2015 Jul 30;1(2):025002.
    https://doi.org/10.1088/2057-1976/1/2/025002
  11. Hamid Q, Wang C, Snyder JE, Williams S, Liu Y, Sun W. Maskless fabrication of cell-laden microuidic chips with localized surface functionalization for the co-culture of cancer cells. Biofabrication. 2015 Mar 2;7(1):015012.
    https://doi.org/10.1088/1758-5090/7/1/015012
  12. Hamid Q, Wang C, Zhao Y, Snyder JE, Sun W. Fabrication of biological microuidics using a digital microfabrication system. Journal of Manufacturing Science and Engineering. 2014 Dec 1;136(6).
    https://doi.org/10.1115/1.4028419
  13. Snyder JE, Hunger PM, Wang C, Hamid Q, Wegst UG, Sun W. Combined multi-nozzle deposition and freeze casting process to superimpose two porous networks for hierarchical three-dimensional microenvironment. Biofabrication. 2014 Jan 15;6(1):015007.
    https://doi.org/10.1115/ISFA2012-7105
  14. Hamid Q, Snyder JE, Wang C, Timmer M, Hammer J, Guceri S, Sun W. Fabrication of three-dimensional scaolds using precision extrusion deposition with an assisted cooling device.Biofabrication. 2011 Jul 5;3(3):034109.
    https://doi.org/10.1088/1758-5082/3/3/034109
  15. Snyder JE, Hamid Q, Wang C, Chang R, Emami K, Wu H, Sun W. Bioprinting cell-laden matrigel for radioprotection study of liver by pro-drug conversion in a dual-tissue microuidic chip. Biofabrication. 2011 Sep 1;3(3):034112.
    https://doi.org/10.1088/1758-5082/3/3/034112


Skills

  1. Analysis: Python, MatLab
  2. Web Design: HTML, JavaScript
  3. Computer Aided Design & Manufacturing (CAD/CAM) software: AutoDesk / Fusion 360, ProEngineer/PTCreo, OpenSCad
  4. 3D Printing: Fuse Desposition Modeling (FDM), Fused Filament Fabrication (FFF), Stereolithography (SLA)
  5. Replica Molding: Gallium, PDMS



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